Blunt solid organ injury and early pharmacologic thromboprophylaxis: A systematic review
DOI:
https://doi.org/10.35381/s.v.v10i2.5084Keywords:
venous thromboembolism, abdominal trauma, anticoagulants, (Source: DeCS).Abstract
Nonoperatively managed blunt abdominal solid organ injury requires balancing initial hemorrhagic risk with prevention of venous thromboembolism. Objectives: To synthesize the evidence on the effectiveness and safety of early pharmacologic thromboprophylaxis versus delayed initiation in blunt hepatic, splenic, or renal injuries. Methods: A systematic review without meta-analysis was conducted following PRISMA 2020. PubMed/MEDLINE, Embase, Scopus, Web of Science, Cochrane Library, and LILACS. Results: Early thromboprophylaxis, particularly within the first 24–48 hours, was associated with fewer thromboembolic events in selected patients. Conclusions: The evidence suggests clinical benefit from early initiation in stable patients without active bleeding, although it should not be generalized to high-risk injuries.
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